Tuesday, 23rd of January, 16.00
(16.00 Coffee & Cake in the foyer, 16.30 talk & discussion)
Lecture Hall III
Lipid Nanoparticles represent the most advanced technology for delivery of nucleic acid. The particles exhibit a well-designed core-shell structure containing ordered lipid mesophases that encapsulate nucleic acid. We discuss distinct pH dependent structural transitions in bulk phases of cationic ionizable lipids and their role in nucleic acid transfer.
These structural transitions are related to gene delivery activity. We show that understanding the content and release kinetics of lipid nanoparticles that contain multiple nucleic acid species, allows for the design of regulatory motives, e.g. feed forward loops, resulting in tailored expression kinetics.